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Attentional Control and Intelligence: MRI Orbital Frontal Gray Matter and Neuropsychological Correlates

Institution:
1Department of Psychology, University of Massachusetts, Boston, MA, USA.
2Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, USA.
Publisher:
Hindawi Publishing Corporation
Publication Date:
May-2015
Volume Number:
2015
Pages:
354186
Citation:
Behav Neurol. 2015 May; 2015: 354186.
PubMed ID:
26101457
PMCID:
PMC4460198
ISBN:
Appears in Collections:
PNL, NA-MIC, SLICER
Sponsors:
K02 MH001110/MH/NIMH NIH HHS/United States
R01 MH050747/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH063360/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Nestor P.G., Nakamura M., Niznikiewicz M., Levitt J.J., Newell D.T., Shenton M.E., McCarley R.W. Attentional Control and Intelligence: MRI Orbital Frontal Gray Matter and Neuropsychological Correlates. Behav Neurol. 2015 May; 2015: 354186. PMID: 26101457. PMCID: PMC4460198.
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Attentional control is a key function of working memory that is hypothesized to play an important role in psychometric intelligence. To test the neuropsychological underpinnings of this hypothesis, we examined full-scale IQ, as measured by the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), and attentional control, as measured by Trails B response time and Wisconsin Card Sorting (WCS) test perseverative errors in 78 healthy participants, 25 of whom also had available magnetic resonance imaging (MRI) gray matter volume studies of the orbital frontal cortex (OFC) parcellated into three regions: gyrus rectus, middle orbital gyrus, and lateral orbital gyrus. Hierarchical regression indicated that Trails B response time specifically explained 15.13% to 19.18% of the variation in IQ and WCS perseverative errors accounted for an additional 8.12% to 11.29% of the variance. Full-scale IQ correlated very strongly with right middle orbital gyrus gray matter volume (r = 0.610, p = 0.002), as did Trails B response time with left middle orbital gyrus gray matter volume (r = −0.608, p = 0.003). Trails B response time and right middle orbital gyrus gray matter volume jointly accounted for approximately 32.95% to 54.82% of the variance in IQ scores. These results provided evidence of the unique contributions of attentional control and OFC gray matter to intelligence.

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