Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

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Image Guided Focused Ultrasound: Development of a Comprehensive Treatment Planning, Monitoring, Control, and Assessment

Institution:
1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Cleveland Clinic, Cleveland, Ohio, USA.
Publisher:
BioMed Central
Publication Date:
Jun-2015
Journal:
J Ther Ultrasound.
Volume Number:
3
Issue Number:
Suppl 1
Pages:
P10
Citation:
J Ther Ultrasound. 2015 Jun; 3(Suppl 1): P10.
PMCID:
PMC4489751
Appears in Collections:
FUS, NCIGT, SLICER
Sponsors:
R25 CA089017/CA/NCI NIH HHS/United States
P01 CA174645/CA/NCI NIH HHS/United States
P41 EB015898/EB/NIBIB NIH HHS/United States
P41 RR019703/RR/NCRR NIH HHS/United States
Generated Citation:
Arvanitis C.D., Clement G., McDannold N. Image Guided Focused Ultrasound: Development of a Comprehensive Treatment Planning, Monitoring, Control, and Assessment. J Ther Ultrasound. 2015 Jun; 3(Suppl 1): P10. PMCID: PMC4489751.
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MRgFUS offers unambiguous advantages over other current treatment modalities, as it is noninvasive and does not use ionizing radiation. Further, ultrasonically-controlled stable and inertial microbubble oscillations exert forces that can, among others, activate cell’s mechanoreceptors, disrupt cellular and vascular membranes, accelerate the dissolution of blood clots, enhance thermal ablation, and induce localized tissue erosionetic. FUS can also be used transcranially for tumor ablation, blood-brain barrier disruption, neuromodulation, etc. Harnessing and, potentially, combining these abilities holds great promise for therapy and diagnosis of cancer and cardiovascular and central nervous system diseases and disorders. For the wide-spread use of these approaches, development of methods and technology to enable precise planning, monitoring and control, and assessment of their outcome are essential.