Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Anterior Commissural White Matter Fiber Abnormalities in First-episode Psychosis: A Tractography Study

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Publication Date:
Schizophr Res
Volume Number:
Issue Number:
Schizophr Res. 2015 Mar;162(1-3):29-34.
PubMed ID:
Anterior commissure (AC), Diffusion Tensor Magnetic Resonance Imaging (dMRI), First-episode schizophrenia, Fractional anisotropy (FA), Radial diffusivity (RD), Tractography
Appears in Collections:
R01 MH102377/MH/NIMH NIH HHS/United States
R01 MH082918/MH/NIMH NIH HHS/United States
UL1 RR025758/RR/NCRR NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 AG042512/AG/NIA NIH HHS/United States
Generated Citation:
Kikinis Z., Fitzsimmons J., Dunn C., Vu M-A., Makris N., Bouix S., Goldstein J.M., Mesholam-Gately R.I., Petryshen T., Del Re E.C., Wojcik J., Seidman L.J., Kubicki M. Anterior Commissural White Matter Fiber Abnormalities in First-episode Psychosis: A Tractography Study. Schizophr Res. 2015 Mar;162(1-3):29-34. PMID: 25667192. PMCID: PMC4339098.
Downloaded: 654 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

BACKGROUND: The Anterior Commissure (AC) is an important interhemispheric pathway that connects contralateral temporal lobes and orbitofrontal areas. The role of the AC is not yet well understood, although abnormalities in this white matter tract have been reported in patients diagnosed with chronic schizophrenia. However, it is not known whether changes in the AC are present at earlier stages of the disease. METHODS: Diffusion Magnetic Resonance Images (dMRI) were acquired from 17 First Episode Schizophrenia Patients (FESZ) and 20 healthy controls. The AC was reconstructed using a streamline tractography approach. DMRI measures, including Fractional Anisotropy (FA), Trace, Axial Diffusivity (AD) and Radial Diffusivity (RD) were computed in order to assess microstructural changes in the AC. RESULTS: FA was reduced, while trace and RD showed increases in FESZ. AD did not show differences between groups. CONCLUSION: The observed changes in these dMRI measures, namely reductions in FA and increases in trace and RD, without changes in AD, likely point to myelin abnormalities of this white matter tract, and provide evidence of white matter pathology extant in the early phases of schizophrenia.

Additional Material
1 File (38.846kB)
KikinisZ-SchizophrRes2015-fig1.jpg (38.846kB)