• Internal Web

• About the SPL
  • Overview
  • Facilities
  • People
  • Projects and Labs
• Resources
  • Publication DB
  • Image Gallery
  • Abstracts DB
  • Software/Data
  • Training/Tutorials
• More
  • Visiting the SPL
  • Contact Us
  • Giving
  • Web Archive

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia

Institution:	Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany;
Publisher:	HighWire
Publication Date:	May-2016
Journal:	Schizophr Bull
Volume Number:	42
Issue Number:	3
Pages:	762-71
Citation:	Schizophr Bull. 2016 May;42(3):762-71.
PubMed ID:	27009248
PMCID:	PMC4838095
Keywords:	arcuate fasciculus, cingulum bundle, cognitive impairments, diffusion MRI, inferior longitudinal fasciculus, lateralization, positive symptoms, superior longitudinal fasciculus, uncinate fasciculus
Appears in Collections:	NAC, PNL, SLICER, SPL
Sponsors:	R01 MH102377/MH/NIMH NIH HHS/United States K05 MH070047/MH/NIMH NIH HHS/United States P50 MH080272/MH/NIMH NIH HHS/United States R01 MH074794/MH/NIMH NIH HHS/United States UL1 RR025758/RR/NCRR NIH HHS/United States T32 MH016259/MH/NIMH NIH HHS/United States R01 AG042512/AG/NIA NIH HHS/United States P41 EB015902/EB/NIBIB NIH HHS/United States
Generated Citation:	Seitz J., Zuo J.X., Lyall A.E., Makris N., Kikinis Z., Bouix S., Pasternak O., Fredman E., Duskin J., Goldstein J.M., Petryshen T.L., Mesholam-Gately R.I., Wojcik J., McCarley R.W., Seidman L.J., Shenton M.E., Koerte I.K., Kubicki M. Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia. Schizophr Bull. 2016 May;42(3):762-71. PMID: 27009248. PMCID: PMC4838095.
Downloaded:	398 times. [view map]
Paper:	Download, View online
Export citation:	Bibtex Text Medline XML
Google Scholar:	link

PURPOSE: Tractography is the most anatomically accurate method for delineating white matter tracts in the brain, yet few studies have examined multiple tracts using tractography in patients with schizophrenia (SCZ). We analyze 5 white matter connections important in the pathophysiology of SCZ: uncinate fasciculus, cingulum bundle (CB), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus, and arcuate fasciculus (AF). Additionally, we investigate the relationship between diffusion tensor imaging (DTI) markers and neuropsychological measures. METHODS: High-resolution DTI data were acquired on a 3 Tesla scanner in 30 patients with early-course SCZ and 30 healthy controls (HC) from the Boston Center for Intervention Development and Applied Research study. After manually guided tracts delineation, fractional anisotropy (FA), trace, radial diffusivity (RD), and axial diffusivity (AD) were calculated and averaged along each tract. The association of DTI measures with the Scales for the Assessment of Negative and Positive Symptoms and neuropsychological measures was evaluated. RESULTS: Compared to HC, patients exhibited reduced FA and increased trace and RD in the right AF, CB, and ILF. A discriminant analysis showed the possible use of FA of these tracts for better future group membership classifications. FA and RD of the right ILF and AF were associated with positive symptoms while FA and RD of the right CB were associated with memory performance and processing speed. CONCLUSION: We observed white matter alterations in the right CB, ILF, and AF, possibly caused by myelin disruptions. The structural abnormalities interact with cognitive performance, and are linked to clinical symptoms.

Seitz-SchizophrBull2016-fig1.jpg (244.354kB)