Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

The Challenge of Mapping the Human Connectome Based on Diffusion Tractography

Maier-Hein K.H., Neher P.F., Houde J-C., Côté M-A., Garyfallidis E., Zhong J., Chamberland M., Yeh F-C., Lin Y-C., Ji Q., Reddick W.E., Glass J.O., Chen D.Q., Feng Y., Gao C., Wu Y., Ma J., Renjie H., Li Q., Westin C-F., Deslauriers-Gauthier S., González J.O.O., Paquette M., St-Jean S., Girard G., Rheault F., Sidhu J., Tax C.M.W., Guo F., Mesri H.Y., Dávid S., Froeling M., Heemskerk A.M., Leemans A., Boré A., Pinsard B., Bedetti C., Desrosiers M., Brambati S., Doyon J., Sarica A., Vasta R., Cerasa A., Quattrone A., Yeatman J., Khan A.R., Hodges W., Alexander S., Romascano D., Barakovic M., Auría A., Esteban O., Lemkaddem A., Thiran J-P., Cetingul H.E., Odry B.L., Mailhe B., Nadar M.S., Pizzagalli F., Prasad G., Villalon-Reina J.E., Galvis J., Thompson P.M., Requejo F.D.S., Laguna P.L., Lacerda L.M., Barrett R., Dell'Acqua F., Catani M., Petit L., Caruyer E., Daducci A., Dyrby T.B., Holland-Letz T., Hilgetag C.C., Stieltjes B., Descoteaux M.
Institution:
Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany. k.maier-hein@dkfz.de.
Publication Date:
Nov-2017
Journal:
Nat Commun
Volume Number:
8
Issue Number:
1
Pages:
1349
Citation:
Nat Commun. 2017 Nov 7;8(1):1349.
PubMed ID:
29116093
PMCID:
PMC5677006
Appears in Collections:
NAC, LMI, NCIGT, SPL
Sponsors:
Wellcome Trust/United Kingdom
P41 EB015898/EB/NIBIB NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
R01 CA090246/CA/NCI NIH HHS/United States
Generated Citation:
Maier-Hein K.H., Neher P.F., Houde J-C., Côté M-A., Garyfallidis E., Zhong J., Chamberland M., Yeh F-C., Lin Y-C., Ji Q., Reddick W.E., Glass J.O., Chen D.Q., Feng Y., Gao C., Wu Y., Ma J., Renjie H., Li Q., Westin C-F., Deslauriers-Gauthier S., González J.O.O., Paquette M., St-Jean S., Girard G., Rheault F., Sidhu J., Tax C.M.W., Guo F., Mesri H.Y., Dávid S., Froeling M., Heemskerk A.M., Leemans A., Boré A., Pinsard B., Bedetti C., Desrosiers M., Brambati S., Doyon J., Sarica A., Vasta R., Cerasa A., Quattrone A., Yeatman J., Khan A.R., Hodges W., Alexander S., Romascano D., Barakovic M., Auría A., Esteban O., Lemkaddem A., Thiran J-P., Cetingul H.E., Odry B.L., Mailhe B., Nadar M.S., Pizzagalli F., Prasad G., Villalon-Reina J.E., Galvis J., Thompson P.M., Requejo F.D.S., Laguna P.L., Lacerda L.M., Barrett R., Dell'Acqua F., Catani M., Petit L., Caruyer E., Daducci A., Dyrby T.B., Holland-Letz T., Hilgetag C.C., Stieltjes B., Descoteaux M. The Challenge of Mapping the Human Connectome Based on Diffusion Tractography. Nat Commun. 2017 Nov 7;8(1):1349. PMID: 29116093. PMCID: PMC5677006.
Downloaded: 109 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.

Additional Material
1 File (204.685kB)
Maier-Hein-NatCommun2017-fig1.jpg (204.685kB)