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Prospective Clinical Implementation of a Novel Magnetic Resonance Tracking Device for Real-Time Brachytherapy Catheter Positioning

Institution:
1Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: jfdearcos@gmail.com.
2Departments of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA.
3MRI Interventions Inc., Irvine, CA, USA.
4Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
5Siemens Healthineers, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Nov-2017
Journal:
Int J Radiat Oncol Biol Phys
Volume Number:
99
Issue Number:
3
Pages:
618-26
Citation:
Int J Radiat Oncol Biol Phys. 2017 Nov 1;99(3):618-26.
PubMed ID:
28843373
PMCID:
PMC5720929
Appears in Collections:
NCIGT, SPL
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
R21 CA167800/CA/NCI NIH HHS/United States
Generated Citation:
de Arcos J., Schmidt E.J., Wang W., Tokuda J., Vij K., Seethamraju R.T., Damato A.L., Dumoulin C.L., Cormack R.A., Viswanathan A.N. Prospective Clinical Implementation of a Novel Magnetic Resonance Tracking Device for Real-Time Brachytherapy Catheter Positioning. Int J Radiat Oncol Biol Phys. 2017 Nov 1;99(3):618-26. PMID: 28843373. PMCID: PMC5720929.
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PURPOSE: We designed and built dedicated active magnetic resonance (MR)-tracked (MRTR) stylets. We explored the role of MRTR in a prospective clinical trial. METHODS AND MATERIALS: Eleven gynecologic cancer patients underwent MRTR to rapidly optimize interstitial catheter placement. MRTR catheter tip location and orientation were computed and overlaid on images displayed on in-room monitors at rates of 6 to 16 frames per second. Three modes of actively tracked navigation were analyzed: coarse navigation to the approximate region around the tumor; fine-tuning, bringing the stylets to the desired location; and pullback, with MRTR stylets rapidly withdrawn from within the catheters, providing catheter trajectories for radiation treatment planning (RTP). Catheters with conventional stylets were inserted, forming baseline locations. MRTR stylets were substituted, and catheter navigation was performed by a clinician working inside the MRI bore, using monitor feedback. RESULTS: Coarse navigation allowed repositioning of the MRTR catheters tips by 16 mm (mean), relative to baseline, in 14 ± 5 s/catheter (mean ± standard deviation [SD]). The fine-tuning mode repositioned the catheter tips by a further 12 mm, in 24 ± 17 s/catheter. Pullback mode provided catheter trajectories with RTP point resolution of ∼1.5 mm, in 1 to 9 s/catheter. CONCLUSIONS: MRTR-based navigation resulted in rapid and optimal placement of interstitial brachytherapy catheters. Catheters were repositioned compared with the initial insertion without tracking. In pullback mode, catheter trajectories matched computed tomographic precision, enabling their use for RTP.