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Automated versus Manual Segmentation of Brain Region Volumes in Former Football Players

Institution:
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Mar-2018
Journal:
Neuroimage Clin
Volume Number:
18
Pages:
888-896
Citation:
Neuroimage Clin. 2018 Mar 21;18:888-96.
PubMed ID:
29876273
PMCID:
PMC5988230
Keywords:
Chronic traumatic encephalopathy, Head trauma, Magnetic resonance imaging, Neuroimaging, Traumatic brain injury
Appears in Collections:
PNL, NAC, SPL
Sponsors:
R01 NS078337/NS/NINDS NIH HHS/United States
R01 NS100952/NS/NINDS NIH HHS/United States
F31 NS081957/NS/NINDS NIH HHS/United States
F32 NS096803/NS/NINDS NIH HHS/United States
P30 AG013846/AG/NIA NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
T32 GM074905/GM/NIGMS NIH HHS/United States
Generated Citation:
Guenette J.P., Stern R.A., Tripodis Y., Chua A.S., Schultz V., Sydnor V.J., Somes N., Karmacharya S., Lepage C., Wrobel P., Alosco M.L., Martin B.M., Chaisson C.E., Coleman M.J., Lin A.P., Pasternak O., Makris N., Shenton M.E., Koerte I.K. Automated versus Manual Segmentation of Brain Region Volumes in Former Football Players. Neuroimage Clin. 2018 Mar 21;18:888-96. PMID: 29876273. PMCID: PMC5988230.
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OBJECTIVES: To determine whether or not automated FreeSurfer segmentation of brain regions considered important in repetitive head trauma can be analyzed accurately without manual correction. MATERIALS AND METHODS: 3 T MR neuroimaging was performed with automated FreeSurfer segmentation and manual correction of 11 brain regions in former National Football League (NFL) players with neurobehavioral symptoms and in control subjects. Automated segmentation and manually-corrected volumes were compared using an intraclass correlation coefficient (ICC). Linear mixed effects regression models were also used to estimate between-group mean volume comparisons and to correlate former NFL player brain volumes with neurobehavioral factors. RESULTS: Eighty-six former NFL players (55.2 ± 8.0 years) and 22 control subjects (57.0 ± 6.6 years) were evaluated. ICC was highly correlated between automated and manually-corrected corpus callosum volumes (0.911), lateral ventricular volumes (right 0.980, left 0.967), and amygdala-hippocampal complex volumes (right 0.713, left 0.731), but less correlated when amygdalae (right -0.170, left -0.090) and hippocampi (right 0.539, left 0.637) volumes were separately delineated and also less correlated for cingulate gyri volumes (right 0.639, left 0.351). Statistically significant differences between former NFL player and controls were identified in 8 of 11 regions with manual correction but in only 4 of 11 regions without such correction. Within NFL players, manually corrected brain volumes were significantly associated with 3 neurobehavioral factors, but a different set of 3 brain regions and neurobehavioral factor correlations was observed for brain region volumes segmented without manual correction. CONCLUSIONS: Automated FreeSurfer segmentation of the corpus callosum, lateral ventricles, and amygdala-hippocampus complex may be appropriate for analysis without manual correction. However, FreeSurfer segmentation of the amygdala, hippocampus, and cingulate gyrus need further manual correction prior to performing group comparisons and correlations with neurobehavioral measures.