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An Annotated Test-retest Collection of Prostate Multiparametric MRI

Institution:
1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2PixelMed Publishing, Bangor, PA, USA.
3Isomics Inc., Cambridge, MA, USA.
Publisher:
Nature Publishing Group
Publication Date:
Dec-2018
Journal:
Sci Data
Volume Number:
5
Pages:
180281
Citation:
Sci Data. 2018 Dec 4;5:180281.
PubMed ID:
30512014
PMCID:
PMC6278692
Appears in Collections:
NCIGT, SPL
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
U01 CA151261/CA/NCI NIH HHS/United States
U24 CA180918/CA/NCI NIH HHS/United States
Generated Citation:
Fedorov A., Schwier M., Clunie D., Herz C., Pieper S., Kikinis R., Tempany C., Fennessy F. An Annotated Test-retest Collection of Prostate Multiparametric MRI. Sci Data. 2018 Dec 4;5:180281. PMID: 30512014. PMCID: PMC6278692.
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Multiparametric Magnetic Resonance Imaging (mpMRI) is widely used for characterizing prostate cancer. Standard of care use of mpMRI in clinic relies on visual interpretation of the images by an expert. mpMRI is also increasingly used as a quantitative imaging biomarker of the disease. Little is known about repeatability of such quantitative measurements, and no test-retest datasets have been available publicly to support investigation of the technical characteristics of the MRI-based quantification in the prostate. Here we present an mpMRI dataset consisting of baseline and repeat prostate MRI exams for 15 subjects, manually annotated to define regions corresponding to lesions and anatomical structures, and accompanied by region-based measurements. This dataset aims to support further investigation of the repeatability of mpMRI-derived quantitative prostate measurements, study of the robustness and reliability of the automated analysis approaches, and to support development and validation of new image analysis techniques. The manuscript can also serve as an example of the use of DICOM for standardized encoding of the image annotation and quantification results.