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Impact of Aeration Change and Beam Arrangement on the Robustness of Proton Plans

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Publication Date:
J Appl Clin Med Phys
Volume Number:
Issue Number:
J Appl Clin Med Phys. 2019 Mar;20(3):14-21.
PubMed ID:
adaptive radiation therapy, nasopharyngeal carcinoma, paranasal sinus cancer, proton
Appears in Collections:
P01 CA21239//National Institutes of Health
CA059267//National Institutes of Health
U54 EB005149//National Institutes of Health
Generated Citation:
Shusharina N., Fullerton B., Adams J.A., Sharp G.C., Chan A.W. Impact of Aeration Change and Beam Arrangement on the Robustness of Proton Plans. J Appl Clin Med Phys. 2019 Mar;20(3):14-21. PMID: 30756466. PMCID: PMC6414139.
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This study determines the impact of change in aeration in sinonasal cavities on the robustness of passive-scattering proton therapy plans in patients with sinonasal and nasopharyngeal malignancies. Fourteen patients, each with one planning CT and one CT acquired during radiotherapy were studied. Repeat and planning CTs were rigidly aligned and contours were transferred using deformable registration. The amount of air, tumor, and fluid within the cavity containing the tumor were measured on both CTs. The original plans were recalculated on the repeat CT. Dosimetric changes were measured for the targets and critical structures. Median decrease in gross tumor volume (GTV) was 19.8% and correlated with the time of rescan. The median change in air content was 7.1% and correlated with the tumor shrinkage. The median of the mean dose Dmean change was +0.4% for GTV and +0.3% for clinical target volume. Median change in the maximum dose Dmax of the critical structures were as follows: optic chiasm +0.66%, left optic nerve +0.12%, right optic nerve +0.38%, brainstem +0.6%. The dose to the GTV decreased by more than 5% in 1 case, and the dose to critical structure(s) increased by more than 5% in three cases. These four patients had sinonasal cancers and were treated with anterior proton fields that directly transversed through the involved sinus cavities. The change in dose in the replanning was strongly correlated with the change in aeration (P = 0.02). We found that the change in aeration in the vicinity of the target and the arrangement of proton beams affected the robustness of proton plan.