Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

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Deep Learning-Based Automatic Segmentation of Lumbosacral Nerves on CT for Spinal Intervention: A Translational Study

Institution:
1From the Orthopedic Department, Shanghai Tenth People's Hospital (G.F., C.F., D.W., S.H.), Tongji University School of Medicine, Shanghai, China tjhss7418@tongji.edu.cn gfan@tongji.edu.cn.
2 Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA,USA.
Publication Date:
Jun-2019
Journal:
AJNR Am J Neuroradiol
Volume Number:
40
Issue Number:
6
Pages:
1074-81
Citation:
AJNR Am J Neuroradiol. 2019 Jun;40(6):1074-81.
PubMed ID:
31147353
PMCID:
PMC6746413
Appears in Collections:
NCIGT, SPL
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
CSC (201706260169), Shanghai Hospital Development Center (16CR3017A)
Generated Citation:
Fan G., Liu H., Wu Z., Li Y., Feng C., Wang D., Luo J., Wells III W.M., He S. Deep Learning-Based Automatic Segmentation of Lumbosacral Nerves on CT for Spinal Intervention: A Translational Study. AJNR Am J Neuroradiol. 2019 Jun;40(6):1074-81. PMID: 31147353. PMCID: PMC6746413.
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BACKGROUND AND PURPOSE: 3D reconstruction of a targeted area ("safe" triangle and Kambin triangle) may benefit the viability assessment of transforaminal epidural steroid injection, especially at the L5/S1 level. However, manual segmentation of lumbosacral nerves for 3D reconstruction is time-consuming. The aim of this study was to investigate the feasibility of deep learning-based segmentation of lumbosacral nerves on CT and the reconstruction of the safe triangle and Kambin triangle. MATERIALS AND METHODS: A total of 50 cases of spinal CT were manually labeled for lumbosacral nerves and bones using Slicer 4.8. The ratio of training/validation/testing was 32:8:10. A 3D U-Net was adopted to build the model SPINECT for automatic segmentations of lumbosacral structures. The Dice score, pixel accuracy, and Intersection over Union were computed to assess the segmentation performance of SPINECT. The areas of Kambin and safe triangles were measured to validate the 3D reconstruction. RESULTS: The results revealed successful segmentation of lumbosacral bone and nerve on CT. The average pixel accuracy for bone was 0.940, and for nerve, 0.918. The average Intersection over Union for bone was 0.897 and for nerve, 0.827. The Dice score for bone was 0.945, and for nerve, it was 0.905. There were no significant differences in the quantified Kambin triangle or safe triangle between manually segmented images and automatically segmented images (P > .05). CONCLUSIONS: Deep learning-based automatic segmentation of lumbosacral structures (nerves and bone) on routine CT is feasible, and SPINECT-based 3D reconstruction of safe and Kambin triangles is also validated.