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Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia

Institution:
Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Publication Date:
Mar-2019
Journal:
Schizophr Bull
Volume Number:
45
Issue Number:
2
Pages:
386-95
Citation:
Schizophr Bull. 2019 Mar 7;45(2):386-95.
PubMed ID:
29618096
PMCID:
PMC6403063
Keywords:
gray matter, morphology, mutual information, schizophrenia, white matter
Appears in Collections:
NAC, PNL, SPL
Sponsors:
R21 MH109819/MH/NIMH NIH HHS/United States
T32 MH016259/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH102377/MH/NIMH NIH HHS/United States
R01 MH092380/MH/NIMH NIH HHS/United States
U01 CA199459/CA/NCI NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
UL1 RR025758/RR/NCRR NIH HHS/United States
Generated Citation:
Lyall A.E., Savadjiev P., Del Re E.C., Seitz J., O'Donnell L.J., Westin C-F., Mesholam-Gately R.I., Petryshen T., Wojcik J.D., Nestor P., Niznikiewicz M., Goldstein J., Seidman L.J., McCarley R.W., Shenton M.E., Kubicki M. Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia. Schizophr Bull. 2019 Mar 7;45(2):386-95. PMID: 29618096. PMCID: PMC6403063.
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Schizophrenia has been characterized as a neurodevelopmental disorder, with structural brain abnormalities reported at all stages. However, at present, it remains unclear whether gray and white matter abnormalities represent related or independent pathologies in schizophrenia. In this study, we present findings from an integrative analysis exploring the morphological relationship between gray and white matter in 45 schizophrenia participants and 49 healthy controls. We utilized mutual information (MI), a measure of how much information two variables share, to assess the morphological dependence between gray and white matter in three segments of the corpus callsoum, and the gray matter regions these segments connect: (1) the genu and the left and right rostral middle frontal gyrus (rMFG), (2) the isthmus and the left and right superior temporal gyrus (STG), (3) the splenium and the left and right lateral occipital gyrus (LOG). We report significantly reduced MI between white matter tract dispersion of the right hemispheric callosal connections to the STG and both cortical thickness and area in the right STG in schizophrenia patients, despite a lack of group differences in cortical thickness, surface area, or dispersion. We believe that this reduction in morphological dependence between gray and white matter may reflect a possible decoupling of the developmental processes that shape morphological features of white and gray matter early in life. The present study also demonstrates the importance of studying the relationship between gray and white matter measures, as opposed to restricting analyses to gray and white matter measures independently.