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The Application of DTI to Investigate White Matter Abnormalities in Schizophrenia
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Institution: |
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System–Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, USA. |
Publisher: |
Ann N Y Acad Sci |
Publication Date: |
Dec-2005 |
Volume Number: |
1064 |
Pages: |
134-148 |
Citation: |
Ann N Y Acad Sci. 2005 Dec;1064:134-48. |
PubMed ID: |
16394153 |
PMCID: |
PMC2768113 |
Keywords: |
DTI Stochastic Tractography, Schizophrenia, Projects:DTIStochasticTractographyClinical |
Appears in Collections: |
LMI, PNL, SLICER |
Sponsors: |
NIH R03 MH 068464-02 NIH R01 NS 39335 NIH R01 MH 40799 NIH K02 MH 01110 NIH R01 MH 50747 |
Generated Citation: |
Kubicki M., Westin C-F., McCarley R.W., Shenton M.E. The Application of DTI to Investigate White Matter Abnormalities in Schizophrenia. Ann N Y Acad Sci. 2005 Dec;1064:134-48. PMID: 16394153. PMCID: PMC2768113. |
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Schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the general population, with often devastating effects on the psychological and financial resources of the patient, family, and larger community. The etiology of schizophrenia is not known, although it likely involves several interacting biological and environmental factors that predispose an individual to schizophrenia. However, although the underlying pathology remains unknown, it has been believed that brain abnormalities would ultimately be linked to the etiology of schizophrenia. This theory was rekindled in the 1970s, when the first computer-assisted tomography (CT) study showed enlarged lateral ventricles in schizophrenia. Since that time, there have been many improvements in MR acquisition and image processing, including the introduction of positron emission tomography (PET), followed by functional MR (fMRI), and diffusion tensor imaging (DTI). These advances have led to an appreciation of the critical role that brain abnormalities play in schizophrenia. While structural MRI has proven to be useful in investigating and detecting gray matter abnormalities in schizophrenia, the investigation of white matter has proven to be more challenging as white matter appears homogeneous on conventional MRI and the fibers connecting different brain regions cannot be appreciated. With the development of DTI, we are now able to investigate white matter abnormalities in schizophrenia.
Additional Material
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